ABSTRACT
Complete molar pregnancy represents part of the spectrum of gestational trophoblastic diseases which are important and interesting part of gynecological oncology. Women diagnosed with complete hydatidiform molar pregnancy are typically counseled that their risk of developing gestational trophoblastic neoplasia [GTN] requiring further management with chemotherapy is 15-20%. To have beta-hCG criteria of persistent gestational trophoblastic disease and to outline beta-hCG levels indicating remission. During the 12 months study period, 80 patients with complete molar pregnancy were followed after evacuation by weekly beta-hCG measurements until either a spontaneous remission where they were shifted to monthly checking or GTN was diagnosed. During the period from the 3[rd] to 8[th] week post-evacuation, patients were subdivided into 4 groups according to their beta-hCG level and their outcome. Fifty seven patients [71.3%] had spontaneous remission, while 23 patients [28.7%] were diagnosed to have GTN. There was no statistically significant difference between the two groups regarding the mean age of the patients and parity, while those women with uterine size larger than date on presentation are more likely to develop GTN with a statistically significant difference between the groups [p value = 0.027]. beta-hCG behavior curves showed that the mean beta-hCG level for the patients with GTN at each week is higher than those patients with remission, with an overall slower decline followed by rising titers seen around the 6[th] week post-evacuation. Those patients who had their hCG level declined < 50 IU/1 during the first 8 weeks post-evacuation can be reassured that they have very low risk of developing GTN while those with beta-hCG level > 200 IU/1, the risk of GTN increased over the subsequent weeks after evacuation peaking at the 8[th] week [Odds ratio = 224] and they should be counseled for chemotherapy